Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors

Introduction: Tyrosine kinase inhibitor drugs (TKIs) are highly effective cancer drugs, yet many TKIs are associated with various forms of cardiotoxicity. The mechanisms underlying these drug-induced adverse events remain poorly understood. We studied mechanisms of TKI-induced cardiotoxicity by inte...

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Autori principali:	Jaehee V. Shim, Yuguang Xiong, Priyanka Dhanan, Rafael Dariolli, Evren U. Azeloglu, Bin Hu, Gomathi Jayaraman, Christoph Schaniel, Marc R. Birtwistle, Ravi Iyengar, Nicole C. Dubois, Eric A. Sobie
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2023-04-01
Serie:	Frontiers in Pharmacology
Soggetti:	mathematical model cardiotoxicity IPSC-CM cardiomyocytes mRNASeq mRNA sequencing kinase inhibitor
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1158222/full
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