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First High-Resolution Crystal Structures of DNA:2′-<i>O</i>-Methyl-RNA Heteroduplexes

Heteroduplexes composed of all-DNA and all-2′-OMe RNA strands do not occur in nature, but they have found application in the development of molecular beacons and could also be used as aptamers or elements of nucleic acid-based nanostructures that will contain such structural motifs. The crystallizat...

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Principais autores: Rafał Dolot, Anna Maciaszek, Barbara Mikołajczyk, Barbara Nawrot
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
coleção:Crystals
Assuntos:
oligonucleotide crystallization
crystal structures
X-ray crystallography
anomalous diffraction
Acesso em linha:https://www.mdpi.com/2073-4352/12/6/760
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