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Mechanism of action and neuroprotective role of nicorandil in ischemic stroke

Nicorandil is a dual mechanism anti-anginal agent that acts as a nitric oxide (NO) donor and a potassium (K+) channel opener. Recent studies have evaluated the effect of nicorandil on ischemic stroke. Neurons have a low tolerance to hypoxia and therefore the brain tissue is significantly vulnerable...

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Principais autores: Maryam Owjfard, Negin Rahmani, Arashk Mallahzadeh, Mahnaz Bayat, Afshin Borhani-Haghighi, Farzaneh Karimi, Mohammad Reza Namavar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-02-01
Serier:Heliyon
Fag:
Ischemic stroke
Nicorandil
K+ channels
Nitric-oxide
Blood pressure
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024026719
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