Cefiderocol resistance in a clinical ST11-KL64 hypervirulent Klebsiella pneumoniae isolate mediated by a novel CirA truncation and SHV-12 β-lactamase

Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections have emerged as a major global public health threat. Cefiderocol is a novel siderophore-conjugated cephalosporin with potent activity to treat severe infections caused by CRKP. In this study, we investigated the underly...

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Autori principali:	Peiyao Zhou, Jiana Fu, Xiaoxia He, Haojin Gao, Chunyang Wu, Fangyou Yu, Ying Zhou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-03-01
Serie:	BMC Microbiology
Soggetti:	Carbapenem-resistant Klebsiella pneumoniae hypervirulent cefiderocol CirA
Accesso online:	https://doi.org/10.1186/s12866-026-04886-z
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