TP53 variants underlying pediatric low‐hypodiploidy B‐cell acute lymphoblastic leukemia demonstrate diverse origins and may persist as a hematopoietic clone in remission

Abstract Pediatric low‐hypodiploidy B‐cell acute lymphoblastic leukemia (LH‐ALL) with TP53 variants has been proposed to be considered a manifestation of Li‐Fraumeni syndrome (LFS). However, our study demonstrates that of the majority the pathogenic variants in the TP53 gene are somatic (70.5%), and...

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Bibliografiske detaljer

Principais autores:	Albert Itov, Karina Ilyasova, Olga Soldatkina, Anna Kazakova, Vladimir Kozeev, Alexandra Semchenkova, Elena Osipova, Elmira Boichenko, Egor Volchkov, Alexander Popov, Elena Zerkalenkova, Julia Roumiantseva, Galina Novichkova, Alexander Karachunskiy, Yulia Olshanskaya
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2024-10-01
Serier:	eJHaem
Fag:	clonal hematopoiesis LH‐ALL Li‐Fraumeni syndrome TP53
Online adgang:	https://doi.org/10.1002/jha2.986
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