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2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane pyrimidine dimers with high yields, and demon...

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Principais autores: Rafał Szabla, Magdalena Zdrowowicz, Paulina Spisz, Nicholas J. Green, Petr Stadlbauer, Holger Kruse, Jiří Šponer, Janusz Rak
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2021-05-01
叢編:Nature Communications
在線閱讀:https://doi.org/10.1038/s41467-021-23300-y
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