A Physiologically-Based Pharmacokinetic Simulation to Evaluate Approaches to Mitigate Efavirenz-Induced Decrease in Levonorgestrel Exposure with a Contraceptive Implant

<i>Background:</i> Levonorgestrel implant is a highly effective hormonal contraceptive, but its efficacy may be compromised when used with cytochrome enzyme inducers such as efavirenz. The primary aim of this study was to evaluate methods of mitigating the drug interaction. <i>Methods:</i> Using a p...

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Principais autores:	Lilian W. Adeojo, Rena C. Patel, Nancy C. Sambol
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-08-01
coleção:	Pharmaceutics
Assuntos:	simulation PBPK model physiologic pharmacokinetic levonorgestrel efavirenz
Acesso em linha:	https://www.mdpi.com/1999-4923/16/8/1050
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