The beauty of symmetry: siRNA phosphorodithioate modifications reduce stereocomplexity, ease analysis, and can improve in vivo potency

Phosphorothioates (PSs) can be essential in stabilizing therapeutic oligonucleotides against enzymatic degradation. However, unless synthesis is performed with stereodefined amidites, each PS introduces a chemically undefined stereocenter, resulting in 2n unique molecules in the final product and af...

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Detalhes bibliográficos

Principais autores:	Sophie Schöllkopf, Stefan Rathjen, Micaela Graglia, Nina Was, Eliot Morrison, Adrien Weingärtner, Lucas Bethge, Judith Hauptmann, Marie Wikström Lindholm
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-12-01
Colecção:	Molecular Therapy: Nucleic Acids
Assuntos:	MT: Oligonucleotides: Therapies and Applications siRNA conjugate GalNAc phosphorothioate phosphorodithioate stereopure
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253124002233
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