LRRK2-mediated NLRC4 phosphorylation differentially regulates IL-1β/IL-18 secretion

In the present study, we explored the relation of LRRK2-kinase phosphorylation of the NLRC4 inflammasome to NLRC4 inflammasome function in normal humans and mice, as well as in patients with Crohn’s disease (CD). We found that LRRK2-kinase was both necessary and sufficient for NLRC4 phosphorylation...

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Hlavní autoři:	Sharmina Deloer, Ivan Fuss, Portia Gough, Anketse Debebe, Mellissa Picker, Robert J. Devita, Inga Peter, Warren Strober
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-10-01
Edice:	Frontiers in Immunology
Témata:	NLRC4 LRRK2 inflammasome Crohn’s disease inflammation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1675137/full
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