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Antineoplastic effect of compounds C14 and P8 on TNBC and radioresistant TNBC cells by stabilizing the K-Ras4BG13D/PDE6δ complex

IntroductionBreast cancer (BC) is the leading cause of cancer-related deaths among women, with triple-negative breast cancer (TNBC) representing one of the most aggressive and treatment-resistant subtypes. In this study, we aimed to evaluate the antitumor potential of C14 and P8 molecules in both TN...

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Principais autores: Dayan A. Carrión-Estrada, Arturo Aguilar-Rojas, Sara Huerta-Yepez, Mayra Montecillo-Aguado, Martiniano Bello, Arturo Rojo-Domínguez, Elena Arechaga-Ocampo, Paola Briseño-Díaz, Marco Antonio Meraz-Ríos, María del Rocío Thompson-Bonilla, Rosaura Hernández-Rivas, Miguel Vargas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-03-01
coleção:Frontiers in Oncology
Assuntos:
K-Ras4B
PDE6δ
breast cancer
triple negative breast cancer (TNBC)
radioresistant
antitumor compounds
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2024.1341766/full
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