Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response

IntroductionInterindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors. While the role of gut microbiota, probiotics and bile acids in modulating drug metabolism, absorption, and bioavailability is increasingly recog...

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Detalhes bibliográficos

Principais autores:	Maja Đanić, Nebojša Pavlović, Natalija Dedić, Dragana Zaklan, Slavica Lazarević, Bojan Stanimirov, Momir Mikov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	drug transport probiotics permeability intestinal microbiota azathioprine inflammatory bowel disease
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1608110/full
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