SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage.

SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous study demonstrated that nsp1 induces RNA modificat...

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Hlavní autoři:	Cheng Huang, Kumari G Lokugamage, Janet M Rozovics, Krishna Narayanan, Bert L Semler, Shinji Makino
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2011-12-01
Edice:	PLoS Pathogens
On-line přístup:	http://europepmc.org/articles/PMC3234236?pdf=render
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