Discovery and characterization of novel hematopoietic prostaglandin D synthase inhibitors from traditional Chinese medicine: the bioactive potential of dihydroberberine in treatments of Duchenne muscular dystrophy and inflammation-related diseases

Inflammation plays a central role in various diseases, necessitating effective anti-inflammatory agents. Prostaglandin D2 (PGD2), a key mediator synthesised by haematopoietic prostaglandin D synthase (H-PGDS), is linked to allergic and inflammatory conditions. This study employed pharmacophore-based...

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Bibliografiske detaljer

Principais autores:	Cheng-Han Li, Min-Che Tung, Cheng-Kuan Tsai, Tz-Chuen Ju, Tien-Sheng Tseng
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2025-12-01
Serier:	Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:	Prostaglandin D2 haematopoietic prostaglandin D synthase pharmacophore-based inhibitor screening traditional Chinese medicine Duchenne muscular dystrophy
Online adgang:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2555624
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