TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage

Abstract Background Cisplatin is a widely used and effective chemotherapeutic agent against cancer. However, nephrotoxicity is one of the most common side effects of cisplatin, and it can proceed to acute kidney injury (AKI). Studies have reported that activation of transient receptor potential anky...

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Hauptverfasser:	Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao, Wei Qin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-10-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Cisplatin Acute kidney injury TRPA1 Endoplasmic reticulum stress Mitochondrial impairment
Online-Zugang:	https://doi.org/10.1186/s12967-023-04351-9
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