Thermo-sensitive hydrogel-mediated locally sequential release of doxorubicin and palbociclib for chemo-immunotherapy of osteosarcoma

Traditional cytotoxic drugs induce immunogenic cell death (ICD) of tumor cells to trigger anti-tumor immunity. Unfortunately, the presence of immunosuppressive cells such as regulatory T cells (Tregs) in tumor microenvironment offsets part of anti-tumor immunity. In this work, we engineered a methox...

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Detalhes bibliográficos

Principais autores:	Ke Li, Duoyi Zhao, Hao Chen, Weilin Zhang, Wei Zhao, Zhiyu Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-12-01
Colecção:	Materials & Design
Assuntos:	Thermo-sensitive hydrogel Locally sequential drug release Immunogenic cell death Antitumor immunity Osteosarcoma chemo- immunotherapy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S026412752200987X
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