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Polyamine–Oligonucleotide Conjugates: 2′-<i>O</i>Me-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes

Oligonucleotides with the sequences 5′-GTG AU<sup>P</sup>A TGC, 5′-GCA TAU<sup>P</sup> CAC and 5′-GU<sup>P</sup>G ATA U<sup>P</sup>GC, where U<sup>P</sup> is 2′-<i>O</i>-propargyl uridine, were subjected to post-synthetic Cu(I)-catalyzed azide–alkyne cycloaddition to attach 1,4,7,10-tetraazacyclodod...

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Gardado en:
Principais autores: Mateusz D. Tomczyk, Mariusz Zalewski, Per T. Jørgensen, Jesper Wengel, Krzysztof Walczak
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-12-01
Series:Pharmaceutics
Assuntos:
oligonucleotide conjugates
duplex stability
thioxanthone
1,8-napthalimide
cyclen
Acceso en liña:https://www.mdpi.com/1999-4923/14/1/66
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