New Insights into Beta-Lactam Resistance of <i>Streptococcus pneumoniae</i>: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x

Reduced amounts of the essential penicillin-binding protein 2x (PBP2x) were detected in two cefotaxime-resistant <i>Streptococcus pneumoniae</i> laboratory mutants C405 and C606. These mutants contain two or four mutations in the penicillin-binding domain of PBP2x, respectively. The transcription of...

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Huvudupphov:	Katharina Peters, Inga Schweizer, Regine Hakenbeck, Dalia Denapaite
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2021-08-01
Serie:	Microorganisms
Ämnen:	<i>Streptococcus pneumoniae</i> penicillin-binding protein PBP2x β-lactam resistance two-component regulatory system CiaRH serine protease HtrA
Länkar:	https://www.mdpi.com/2076-2607/9/8/1685
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