Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications

Abstract Background Meningiomas exhibit a complex biology that, despite notable successes in preclinical studies, contributes to the failures of pharmaceutical clinical trials. Animal models using patient tumor cells closely mimic in vivo conditions but are labor-intensive, costly, and unsuitable fo...

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Hauptverfasser:	Mikkel Schou Andersen, Aaraby Yoheswaran Nielsen, Martin Wirenfeldt, Jeanette Krogh Petersen, Morten Winkler Møller, Christopher L. Powell, Anavaleria Castro, Grayson Herrgott, Tiit Mathiesen, Charlotte Aaberg Poulsen, Birgitte Brinkmann Olsen, Henning Bünsow Boldt, Christian Bonde Pedersen, Bo Halle, Frantz Rom Poulsen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-04-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	Meningioma 3D model Organoid In vitro model DNA methylation Immunohistochemistry
Online-Zugang:	https://doi.org/10.1186/s40478-025-02008-w
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