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Walking to protect against cognitive decline: the role of APOE genotype and sex

Abstract Background The apolipoprotein E (APOE) ε4 allele is a risk factor for late-onset Alzheimer’s disease; however, risk varies by sex and lifestyle. Regular physical activity is known to mitigate cognitive decline; whether the degree of benefit differs by APOE genotype, sex, and race remains un...

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Huvudupphov: Joel S. Burma, Caterina Rosano, John R. Best, Eleanor M. Simonsick, Teresa Liu-Ambrose, Cindy K. Barha
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2026-02-01
Serie:Biology of Sex Differences
Ämnen:
APOE ε4
Physical Activity
Cognitive Decline
Sex Differences
Walking
Länkar:https://doi.org/10.1186/s13293-026-00860-6
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