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mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons

The mechanistic target of rapamycin (mTOR) pathway plays an important role in regulating multiple cellular processes, including cell growth, autophagy, proliferation, protein synthesis, and lipid synthesis, among others. Given the central role of this pathway in multiple cellular processes, it is no...

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Bibliografische gegevens
Hoofdauteurs: Elizabeth D. Buttermore, Gayathri Rajaram Srinivasan, Hellen Jumo, Amanda C. Swanson, Benjamin O’Kelly, Nina R. Makhortova, Mustafa Sahin, Stelios T. Tzannis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2025-07-01
Reeks:Frontiers in Neuroscience
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Online toegang:https://www.frontiersin.org/articles/10.3389/fnins.2025.1595880/full
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