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In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

Abstract Background Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ectopic expression of Zfp521 reprograms fibroblasts and astrocytes into...

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Principais autores: Masoumeh Zarei-Kheirabadi, Mahdi Hesaraki, Sahar Kiani, Hossein Baharvand
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-12-01
Serier:Stem Cell Research & Therapy
Fag:
Adult astrocyte
Conversion
Reprogramming
Neural stem cells
Zfp521
In vivo reprogramming
Online adgang:https://doi.org/10.1186/s13287-019-1448-x
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