Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain

The triple transgenic mouse model of Alzheimer’s disease (3×Tg-AD) is a widely used model that exhibits region-dependent patterns of progressive amyloid-β and tau pathology. Although structural brain abnormalities on magnetic resonance imaging have been observed in 3×Tg-AD mice at later disease stag...

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Detalhes bibliográficos

Principais autores:	Yongxin Li, Ziling Tang, Maohua Yao, Yun Ran, Zuocheng Qiu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2026-08-01
coleção:	Neural Regeneration Research
Assuntos:	3×tg-ad mouse model alzheimer’s disease brain volume brain–behavior correlation diffusion tensor imaging fractional anisotropy magnetic resonance imaging nerve regeneration rna sequencing voxel-based morphometry
Acesso em linha:	https://journals.lww.com/10.4103/NRR.NRR-D-25-00006
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