Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibility of CML-LSCs to tyrosine kinase inhibitor (TKI...

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Principais autores:	Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando
Format:	Artigo
Sprog:	Inglês
Udgivet:	Ferrata Storti Foundation 2020-01-01
Serier:	Haematologica
Online adgang:	https://haematologica.org/article/view/9639
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