Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues

PROTACs represent an emerging field in medicinal chemistry, which has already led to the development of compounds that reached clinical studies. Posttranslational modifications contribute to the complexity of proteomes, with 2846 disease-associated sites. PROTAC field is very advanced in targeting k...

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Bibliografiske detaljer

Principais autores:	Marta Pichlak, Tomasz Sobierajski, Katarzyna M. Błażewska, Edyta Gendaszewska-Darmach
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis Group 2023-12-01
Serier:	Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:	PROTAC posttranslational modifications E3 ubiquitin ligases proteasome degradation collateral degradation structure optimisation
Online adgang:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2254012
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