An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis

Abstract Background Sepsis is caused by the dysregulated immune response due to an initial infection and results in significant morbidity and mortality in humans. Extracellular cold inducible RNA binding protein (eCIRP) is a novel mediator identified in sepsis. We have previously discovered that mic...

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Главные авторы:	Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. Coppa, Monowar Aziz, Ping Wang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2023-02-01
Серии:	Molecular Medicine
Предметы:	Sepsis eCIRP miRNA eCIRP inhibitor Inflammation Apoptosis
Online-ссылка:	https://doi.org/10.1186/s10020-023-00607-8
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