Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Abstract Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly investigated. We conducted a sex-stratified, genome-wid...

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Autori principali:	Youngjune Bhak, Vasilis Raptis, Yunye He, Tomoko Nakanishi, Erin Macdonald-Dunlop, Yoji Sagiya, Takayuki Morisaki, Koichi Matsuda, BioBank Japan Project, The Japan COVID-19 Task Force, Akinori Kanai, Yutaka Suzuki, Yoshiya Oda, Yoichiro Kamatani, Ho Namkoong, Ryunosuke Saiki, Akinori Kimura, Ryuji Koike, Seishi Ogawa, Satoru Miyano, Seiya Imoto, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Anders Mälarstig, Albert Tenesa
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-08-01
Serie:	Scientific Reports
Soggetti:	Proteome profiles Sex-dimorphic protein quantitative trait loci Sex differences
Accesso online:	https://doi.org/10.1038/s41598-025-10031-z
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