Intrapulmonary penetration and pharmacokinetics of siderophore cephalosporin HRS-8427 injection in Chinese healthy subjects

ABSTRACT HRS-8427, a novel siderophore cephalosporin antibiotic, is under development for treating Gram-negative infections. This study evaluated the intrapulmonary penetration and pharmacokinetic (PK) profile of HRS-8427 injection following single and multiple dose administrations in healthy Chines...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Yichen Cao, Yuanyuan Huang, Jinlian Xie, Qian Wu, Shuang Yang, Xiaoyan Yang, Jie Huang, Jinlong Liu, Jie Meng, Guoping Yang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	ASM 2025-12-01
Cyfres:	Antimicrobial Agents and Chemotherapy
Pynciau:	HRS-8427 intrapulmonary pharmacokinetic bronchoalveolar lavage epithelial lining fluid
Mynediad Ar-lein:	https://journals.asm.org/doi/10.1128/aac.00702-25
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!