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Intrapulmonary penetration and pharmacokinetics of siderophore cephalosporin HRS-8427 injection in Chinese healthy subjects

ABSTRACT HRS-8427, a novel siderophore cephalosporin antibiotic, is under development for treating Gram-negative infections. This study evaluated the intrapulmonary penetration and pharmacokinetic (PK) profile of HRS-8427 injection following single and multiple dose administrations in healthy Chines...

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Principais autores: Yichen Cao, Yuanyuan Huang, Jinlian Xie, Qian Wu, Shuang Yang, Xiaoyan Yang, Jie Huang, Jinlong Liu, Jie Meng, Guoping Yang
Format: Artigo
Sprog:Inglês
Udgivet: ASM 2025-12-01
Serier:Antimicrobial Agents and Chemotherapy
Fag:
HRS-8427
intrapulmonary pharmacokinetic
bronchoalveolar lavage
epithelial lining fluid
Online adgang:https://journals.asm.org/doi/10.1128/aac.00702-25
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