Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own recept...

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Detalhes bibliográficos

Principais autores:	Zhigang Shi, Nicole E Pelletier, Jennifer Wong, Baoxin Li, Andrei D Sdrulla, Christopher J Madden, Daniel L Marks, Virginia L Brooks
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-06-01
coleção:	eLife
Assuntos:	sympathetic nerve activity paraventricular nucleus brown adipose tissue glutamatergic neurons thyrotropin releasing hormone leptin
Acesso em linha:	https://elifesciences.org/articles/55357
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