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Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction

Summary: Glutamine:fructose-6-phosphate transaminase 1 (GFPT1) is the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP). A 54-bp exon 9 of GFPT1 is specifically included in skeletal and cardiac muscles to generate a long isoform of GFPT1 (GFPT1-L). We showed that SRSF1 and Rbfox1/2 c...

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Principais autores: Paniz Farshadyeganeh, Mohammad Nazim, Ruchen Zhang, Bisei Ohkawara, Kazuki Nakajima, Mohammad Alinoor Rahman, Farhana Nasrin, Mikako Ito, Jun-ichi Takeda, Kenji Ohe, Yuki Miyasaka, Tamio Ohno, Akio Masuda, Kinji Ohno
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-10-01
Serier:iScience
Fag:
Biological sciences
Biochemistry
Physiology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004223018230
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