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Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires’ disease

IntroductionSevere Legionnaires’ disease (LD) can lead to multi-organ failure or death in 10%–30% of patients. Although hyper-inflammation and immunoparalysis are well described in sepsis and are associated with high disease severity, little is known about the immune response in LD. This study aimed...

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Principais autores: Camille Allam, William Mouton, Hugo Testaert, Christophe Ginevra, Noémie Fessy, Marine Ibranosyan, Ghislaine Descours, Laetitia Beraud, Johann Guillemot, Annelise Chapalain, Chloé Albert-Vega, Jean-Christophe Richard, Laurent Argaud, Arnaud Friggeri, Vanessa Labeye, Yvan Jamilloux, Nathalie Freymond, Fabienne Venet, Gérard Lina, Patricia Doublet, Florence Ader, Sophie Trouillet-Assant, Sophie Jarraud
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-10-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
Legionnaires’ disease
hyper-inflammation
immunoparalysis
immune functional assays
severity
LPS stimulation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1252515/full
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