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Memantine and the Kynurenine Pathway in the Brain: Selective Targeting of Kynurenic Acid in the Rat Cerebral Cortex

Cytoprotective and neurotoxic kynurenines formed along the kynurenine pathway (KP) were identified as possible therapeutic targets in various neuropsychiatric conditions. Memantine, an adamantane derivative modulating dopamine-, noradrenaline-, serotonin-, and glutamate-mediated neurotransmission is...

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Principais autores: Renata Kloc, Ewa M. Urbanska
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-08-01
Serier:Cells
Fag:
memantine
neurodegeneration
kynurenine pathway
kynurenic acid
cortex
Online adgang:https://www.mdpi.com/2073-4409/13/17/1424
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