Peripheral lysosome levels dictate mTORC1 inactivation even when catabolically impaired
Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is a central driver of cell growth that is frequently hyperactivated in cancer. While mTORC1 is activated at the lysosomal surface in response to growth factors and amino acids, the processes governing its inactivation are not fully und...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2026-01-01
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| Serie: | Cell Communication and Signaling |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s12964-026-02659-9 |
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