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Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice

Wear particles from total joint arthroplasties (TJAs) induce chronic inflammation, macrophage infiltration and lead to bone loss by promoting bone destruction and inhibiting bone formation. Inhibition of particle-associated chronic inflammation and the associated bone loss is critical to the success...

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Hlavní autoři: Ning Zhang, Takeshi Utsunomiya, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Ejun Huang, Claire Rhee, Zhenyu Yao, Stuart B. Goodman
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-10-01
Edice:Frontiers in Cell and Developmental Biology
Témata:
wear particles
chronic inflammation
bone loss
mesenchymal stem cells
macrophages
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2021.757830/full
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