Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function

Glutamine is one of the most abundant amino acids in the cell. In mitochondria, glutaminases 1 and 2 (GLS1/2) hydrolyze glutamine to glutamate, which serves as the precursor of multiple metabolites. Here, we show that ammonium generated during GLS1/2-mediated glutaminolysis regulates lysosomal pH an...

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Auteurs principaux:	Jian Xiong, Thi Thu Trang Luu, Kartik Venkatachalam, Guangwei Du, Michael X. Zhu
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-12-01
Collection:	Cells
Sujets:	amino acid starvation autophagy autophagosome glutaminase glutamine lysosomal pH
Accès en ligne:	https://www.mdpi.com/2073-4409/12/1/80
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