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Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases

Abstract Background Transcriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity (ITH) and plasticity can significantly impact diagnosis and patient ma...

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Wedi'i Gadw mewn:
Prif Awduron: Carina Bernardo, Subhayan Chattopadhyay, Natalie Andersson, Pontus Eriksson, Benjamin Medle, Lena Tran, Nour al dain Marzouka, Adam Mattsson, Aymeric Zadoroznyj, Malin Larsson, Fredrik Liedberg, Mattias Höglund, Gottfrid Sjödahl
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2025-07-01
Cyfres:Experimental Hematology & Oncology
Pynciau:
Bladder cancer
Plasticity
Molecular subtypes
Tumor microenvironment
Metastasis
Tumor evolution
Mynediad Ar-lein:https://doi.org/10.1186/s40164-025-00682-z
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