Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity

Abstract: Loss-of-function mutations and deletions in the core components of the epigenetic polycomb repressive complex 2 (PRC2) are associated with poor initial treatment response in T-cell acute lymphoblastic leukemia (T-ALL), but the mechanisms that underpin resistance to individual therapies are...

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Detalhes bibliográficos

Principais autores:	Thomas Lefeivre, Theodora-Ioana Grosu, Cosmin Tudose, Luke Jones, Theresa E. León, Kieran Wynne, Giorgio Oliviero, Owen P. Smith, Amélie Trinquand, Marc R. Mansour, Colm J. Ryan, Jonathan Bond
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-02-01
coleção:	Blood Advances
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S247395292500744X
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