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Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Abstract The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kidney tubule, but still lack the expression of important transport proteins needed f...

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Hoofdauteurs: Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar, Rosalinde Masereeuw
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2022-07-01
Reeks:Journal of Nanobiotechnology
Onderwerpen:
Extracellular vesicles
Kidney tubuloids
Maturation
Organic anion transporter 1
Proteomics
Bioengineered kidney tubules
Online toegang:https://doi.org/10.1186/s12951-022-01506-6
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