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Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells

Abstract Background BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due...

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Principais autores: Tiziana Notarangelo, Lorenza Sisinni, Valentina Condelli, Matteo Landriscina
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-10-01
Serier:Cancer Cell International
Fag:
BRAF
Thyroid carcinoma
EGFR
Vemurafenib
Gefitinib
Online adgang:http://link.springer.com/article/10.1186/s12935-017-0457-z
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