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Sensing and responding to allergic response cytokines through a genetically encoded circuit

The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.

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Bibliografische Detailangaben
Hauptverfasser: Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2017-10-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-017-01211-1
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