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Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

The processing of Amyloid Precursor Proteins (APPs) results in several fragments, including soluble N-terminal ectodomains (sAPPs) and C-terminal intracellular domains (AICD). sAPPs have been ascribed neurotrophic or neuroprotective functions in cell culture, although β-cleaved sAPPs can have delete...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jill S. Wentzell, Bonnie J. Bolkan, Katia Carmine-Simmen, Tracy L. Swanson, Derek T. Musashe, Doris Kretzschmar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2012-04-01
Cyfres:Neurobiology of Disease
Pynciau:
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S0969996112000022
Tagiau: Ychwanegu Tag
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