Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease of hyperinflammation resulting from immune dysregulation due to inherited defects in the cytolytic machinery of NK and T cells. In humans, mutations in seven genes encoding proteins involved in cytolytic effector function...

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主要な著者:	Birthe eJessen, Tamara eKögl, Fernando E. Sepulveda, Genevieve ede Saint Basile, Peter eAichele, Stephan eEhl
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2013-12-01
シリーズ:	Frontiers in Immunology
主題:	Inflammation Cytotoxicity CTL Hemophagocytic lymphohistiocytosis (HLH) virus persistence antigen persistence
オンライン･アクセス:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00448/full
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