In vitro characterization of osteoblasts from craniofacial fibrous dysplasia of bone and their impact on bone homeostasis

Abstract Fibrous Dysplasia (FD) is a benign and rare genetic disease characterized by progressive replacement of normal bone by a non-mineralized matrix. FD is caused by GNAS mutations that increase intracellular cAMP levels. While appendicular lesions have been extensively studied to enhance unders...

Полное описание

Библиографические подробности

Главные авторы:	Johan Sergheraert, Claire Dumortier, Christine Guillaume, Sébastien Laurence, Fabien Bornert, Sophie C. Gangloff, Cédric Mauprivez, Frédéric Velard
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-02-01
Серии:	Orphanet Journal of Rare Diseases
Предметы:	Fibrous dysplasia of bone Primary human osteoblasts Osteoblast differentiation Primary human monocytes Osteoclastogenesis
Online-ссылка:	https://doi.org/10.1186/s13023-026-04262-0
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