An Interpretable PK-Informed Hybrid Model for Voriconazole Exposure Prediction: Roles of CYP2C19 Genotype and Inflammation

Yehui Zhou,1,2,* Yuting Yun,1,2,* Shiting Chen,1,2,* Xinyi Liu,2,3,* Hao Liu,4 Jiaxin Ren,1,2 Mengmeng Lu,1,2 Jing Ling,5 Xuping Yang,5 Zhou Zhou,2 James Afriyie Osei,1,2 Respina Soheili,1,2 Jianjun Zou,2 Nan Hu5 1School of Basic Medicine and Clinical Pharmacy, China...

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Autors principals:	Zhou Y, Yun Y, Chen S, Liu X, Liu H, Ren J, Lu M, Ling J, Yang X, Zhou Z, Osei JA, Soheili R, Zou J, Hu N
Format:	Artigo
Idioma:	Inglês
Publicat:	Dove Medical Press 2026-05-01
Col·lecció:	Drug Design, Development and Therapy
Matèries:	Voriconazole Population Pharmacokinetics Machine Learning hybrid modeling strategy causal mediation analysis plasma concentration prediction.
Accés en línia:	https://www.dovepress.com/an-interpretable-pk-informed-hybrid-model-for-voriconazole-exposure-pr-peer-reviewed-fulltext-article-DDDT
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