Rapamycin alleviates hypothalamic injury in exertional heat stroke rats by activating mitophagy through the mTOR/Pink1/Parkin pathway

Abstract Exertional heat stroke (EHS) causes severe central nervous system damage, with mitochondrial dysfunction and oxidative stress playing major roles. Mitophagy, regulated by the Pink1/Parkin pathway, removes damaged mitochondria. Here, we investigated the potential of rapamycin (RAPA) to reduc...

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Prif Awduron:	Ruxue Chi, Yan Gu, Ran Meng, Lv Xuan, Zhengzhong Sun, Yuxiang Zhang, Jiaxing Wang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2025-10-01
Cyfres:	Scientific Reports
Pynciau:	Heat stroke Hypothalamus Rapamycin Mitophagy Pink1 Parkin
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-025-20313-1
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