Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To understand the structural basis of proline impor...

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Autori principali:	Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-06-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-48921-x
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