Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Abstract Background Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation, which may also be influenced by genetic factors....

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-09-01
Schriftenreihe:	Genome Medicine
Schlagworte:	Autoimmune disease Rheumatoid arthritis Epigenetics DNA methylation Twins
Online-Zugang:	http://link.springer.com/article/10.1186/s13073-018-0575-9
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