Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

α-Glucosidase inhibitors are known to prevent the digestion of carbohydrates and reduce the impact of carbohydrates on blood glucose. To develop novel α-glucosidase inhibitors, a series of 5-fluoro-2-oxindole derivatives (3a ∼ 3v) were synthesized, and their α-glucosidase inhibitory activities were...

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Auteurs principaux:	Jing Lin, Qi-Ming Liang, Yuan-Na Ye, Di Xiao, Li Lu, Meng-Yue Li, Jian-Ping Li, Yu-Fei Zhang, Zhuang Xiong, Na Feng, Chen Li
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-06-01
Collection:	Frontiers in Chemistry
Sujets:	oxindole α-glucosidase inhibition docking kinetics
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fchem.2022.928295/full
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