Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability

To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl- β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR)...

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Autores principales:	Lu Yapeng, Liu Siyuan, Zhao Yu, Zhu Li, Yu Shuqin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Sciendo 2014-06-01
Colección:	Acta Pharmaceutica
Materias:	Z-ligustilide hydroxypropyl-β-cyclodextrin inclusion complex stability bioavailability
Acceso en línea:	http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0012/acph-2014-0012.xml?format=INT
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