Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

Abstract Background Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expression profile of the inhaled PDE4-inhibit...

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Detalhes bibliográficos

Principais autores:	Mirco Govoni, Michele Bassi, Stefano Vezzoli, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Stefano Petruzzelli, Gera L. Jellema, Ebenezer K. Afolabi, Brendan Colgan, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz, Dave Singh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-03-01
coleção:	Respiratory Research
Assuntos:	Gene expression Inflammation Phosphodiesterase 4 inhibitors Biomarkers Chronic obstructive pulmonary disease
Acesso em linha:	http://link.springer.com/article/10.1186/s12931-020-1329-y
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