A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature

Abstract Background A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGSheight) could identify children with non-familial idiopathic short stature (ISS-NF) who carry a poly...

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Autores principales:	John P. Shelley, Mingjian Shi, Josh F. Peterson, Sara L. Van Driest, Jill H. Simmons, Jonathan D. Mosley
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-03-01
Colección:	Genome Medicine
Materias:	Polygenic scores Height Common genetic variation Short stature Idiopathic short stature
Acceso en línea:	https://doi.org/10.1186/s13073-025-01455-3
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